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The MRTC is engaged in studies on the molecular biology determinants of malaria parasites resistance to chloroquine and sulfadoxine-pyrimethamine. Using pfcrt as a marker for chloroquine resistance, O. Doumbo's group developped the genotype-resistance index (GRI) model. They now propose the use a genomic approach to gain a better understanding of the host molecules involved in clearing malaria parasites from the blood stream, and how this relates to pathogenesis. Recent data suggest ethnic and possibly genetic differences in host response to malaria. They confirmed those studies in sympatric genetically isolated Malian populations and are in the process of investigating immune and genetic factors involved in host susceptibility to malaria. In an effort for improved understanding of malaria in pregnancy, ongoing studies perform phenotypic characterization of parasites collected from pregnant women with regard to CSA adhesion. The dynamics of antibodies to various antigens in primiparous and multiparous women is also being investigated.
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