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Her laboratory is interested in understanding the metabolic and signalling processes that are involved in the defence against exogensous and endogenous stresses that the malaria parasites encounter throughout their development in mammalian and insect host. The functions of pathways involved in antioxidant defence and maintenance of redox homeostasis, not only in the parasite as a whole but also in its organelles, are being dissected by reverse genetics and biochemical analyses of recombinantly expressed proteins, including the analyses of biophysical and structural properties of selected proteins. The importance of these metabolic networks for the survival and development of Plasmodium are being studied and it is expected that this work will help to identify parasite-specific mechanisms that are potentially exploitable as future drug targets.
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