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She is involved in analysis of field parasite polymorphism and studies of immune responses to P.falciparum in humans and in Saimiri. Her recent research programmes have focussed on analysis of immune activation in African children with severe and mild malaria and in the squirrel monkey; identification of parasite virulence factors contributing to increased fitness in vivo, and collaborative studies on human genetic susceptibility to malaria in Senegal. The group has made important contributions on the activation of gamma delta T cells, resulting in description of a new class of malaria antigens. The group has very strong, long-standing collaborations with Institutions in endemic areas. Of relevance are the development of tools to quantify immune responses in African chidren (quantitative surface staining and real-time RT-PCR for cytokines), and the development of a Saimiri model of malaria anaemia, together with a battery of tools to study the Saimiri cellular responses. She has established a functional P. falciparum microarray platform in collaboration with the IP Génopole and developed novel genetic tools for P. falciparum.
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